Skyroads (1936) by Keaton

Published October 30, 1936.

The strip has nice hatching and an airplane in flight as well as a Wing Tips panel of facts for the aviation enthusiast. Hollywood of that era is a source of comedy, referring to the Barrymore acting family as the "Burrymores" and providing a James Cagney look-a-like in the central panel. Jumpin' joops! The Jenny biplane portrayed in the strip foreshadows Russell Keaton leaving several years later to start his own, more popular strip, "Flyin' Jenny," featuring an eponymous, lovely female pilot.

Skyroads in 1929 was among the strips created to cash in on heightened interest in aviation following Charles Lindbergh's Atlantic crossing two years earlier. The strip's creators were aviation pioneer Lester J. Maitland and Lt. Dick Calkins, an ex-Army Air Service pilot who was already drawing the Buck Rogers comic strip, according to Wikipedia.

Like Buck Rogers, John F. Dille Co., later known as the National Newspaper Syndicate, syndicated the strip. Maitland and Calkins continued to collaborate on Skyroads until 1933, when Keaton, Calkins' assistant, left his uncredited work on Buck Rogers to take over writing and drawing the strip. Keaton remained until 1939, when Leonard Dworkins, under the pseudonym "Leon Gordon," took over.

The strip wasn't that popular, possibly because, unlike other strips, Skyroads changed its protagonists several times.

Although Wikipedia and other sources cite 1942 as the strip's last year, other research indicates it wrapped up its last original story in 1940 after being renamed "The Flying Legion" earlier that year. It likely ran as reprints from 1940 to 1942. (The Great Skyroads/Speed Spaulding Mystery, https://comicstriphistory.com/2007/02/great-skyroadsspeed-spaulding-mystery.html)