Skull (from Y the Last Man?) by Pia Guerra

I read and really enjoyed the series, but don't have any recollection of a skull being an integral part of the story. I may have simply forgotten though.

I think the skull thematically refers to the fact that all men are dead?

Simple and effective drawing by Guerra.  Still very popular and in high demand with BKV making hits.

Yeah - very cool piece by Pia, with a great placement on the page to really pop it.  I think what you have here is actually Yorick's successor: "Z", the last man...