Amazing Spider-Man #34 (Marvel, 1966)

Kraven the Hunter returns to get revenge for his defeat at the hands of Spider-Man. This issue is only the third appearance of one of the web-slinger's greatest villains -- brought to you by his creators, Stan Lee and Steve Ditko. This classic page has Kraven and Spidey battling hand-to-hand, as the big-game hunter tries to prove himself by besting the strongest quarry he has ever faced. Note that panel one is very similar to the issue's cover!