The New Mutants #98 (Marvel, 1991)

This is the very first story page appearance of Deadpool, one of the most popular comic book characters of all time! This page is also the definition of "fresh to market" as it's the first time the page has ever been at auction, having been buried in a private collection since the 1990s.
On the heels of the massive success of Deadpool's entry into the Marvel Cinematic Universe, the Merc with a Mouth has become a household name, cementing his place in comics fandom. From the mind of renowned creator Rob Liefeld, Deadpool was introduced in the pages of Marvel's New Mutants with this absolutely unbeatable splash image featuring of our hero dramatically poised over a stunned Cable-all rendered in Liefeld's trademark style, which came to define the look of 1990s comics. After a dramatic leadup and only seeing Cable being knocked flat on the previous page, we get this hugely powerful introduction of the character, showing a full shot of Deadpool ready for action... and fans can sense quite a battle brewing!